2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Factor XI

Factor XI

Factor XI

Factor XI is an important protein in the blood coagulation cascade, and is part of the intrinsic coagulation pathway. As a zymogen, Factor XI circulates in an inactive form in the blood. When blood vessels are damaged, Factor XI is activated to Factor XIa, which then activates Factor IX, leading to the activation of Factor X. This cascade ultimately generates thrombin, promoting blood clotting, sealing the blood vessel damage, and stopping bleeding.
Factor XI is crucial for maintaining normal hemostatic function, but abnormal activity can lead to bleeding or thrombosis. Factor XI deficiency (Hemophilia C) is a genetic disorder that predisposes individuals to spontaneous or trauma-induced bleeding. On the other hand, excessive Factor XI activity is associated with thrombosis and may increase the risk of deep vein thrombosis, pulmonary embolism, and stroke[1].

Factor XI Related Products (4):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-156613
    Frunexian
    		Inhibitor
    Frunexian (EP-7041) is a selective and potent inhibitor of coagulation factor XI/activated factor XI, targeting to factor XIa. Frunexian exhibits antithrombotic activity, with no bleeding liability in rat mesenteric arterial puncture model. Frunexian can be used in extracorporeal membrane oxygenation (ECMO) research.
    Frunexian
  • HY-134005
    ISIS 416858
    		Inhibitor
    ISIS 416858, a single-stranded antisense oligodeoxynucleotide, is a potent and selective inhibitor of FXI mRNA expression.
    ISIS 416858
  • HY-E70393J
    Bovine Factor XIa
    Bovine Factor XIa is an enzyme, which is involved in the intrinsic pathway of blood coagulation. Bovine Factor XIa is highly selective and exhibits a minimal extended substrate recognition site of at least five residues long. Bovine Factor XIa is reactive as Bovine Factor IXa (HY-E70393I) does, that it cleaves all the peptides bearing factor IX activation site sequences.
    Bovine Factor XIa
  • HY-143477
    Factor XI-IN-1
    		Inhibitor
    Factor XI-IN-1 (Compound 27) is a factor XI activation inhibitor with an EC50 of 25.14 nM.
    Factor XI-IN-1